Clinical Evidence - Methemoglobin (SpMet^®)

SpMet has been shown to help clinicians noninvasively and continuously assess methemoglobinemia status and determine treatment and additional test options.

Featured Clinical Studies:

Pulse-Oximetric Measurement of Prilocaine-Induced Methemoglobinemia in Regional Anesthesia. Soeding P., Deppe M., Gehring H. Anesth Analg. 2010 Oct;111(4):1065-8.
Severe Methemoglobinemia Detected by Pulse Oximetry. Annabi E.H., Barker S,J. Anesth Analg. 2009;108:898–9.
Measurement of Carboxyhemoglobin and Methemoglobin by Pulse Oximetry: A Human Volunteer Study. Barker S.J., Curry J., Redford D., Morgan S. Anesthesiology. 2006 Nov;105(5):892-7.

Full Citation List of All Available Studies:*

The Usefulness of Noninvasive MetHb Monitoring at HBOT Department (Pulse CO-Oximetry Masimo Rainbow SET RAD-57). Nakashima M., Tsutsumi Y., Ifuku T., Tachibana H., Tamehiro K. , Taki K., Shima H. Crit Care Med. 2010 Vol. 38, No. 12 (Suppl.).
Improved Accuracy of Methemoglobin Detection by Pulse CO-Oximetry during Hypoxia. Feiner J.R., Bickler P.E. Anesth Analg. 2010 Nov;111(5):1160-7.
Pulse Oximeter Methemoglobin Measurements in Patients with Tumescent Anaesthesia and Prilocaine. Boye S., Opp A., Klose A., Schmeller W., Gehring H. Proceedings of the 2010 Annual Meeting of the American Society Anesthesiologists. A886.
Pulse-Oximetric Measurement of Prilocaine-Induced Methemoglobinemia in Regional Anesthesia. Soeding P., Deppe M., Gehring H. Anesth Analg. 2010 Oct;111(4):1065-8.
Accuracy of Methemoglobin Detection by Pulse CO-Oximetry during Hypoxia. Feiner J.R., Bickler P.E., Mannheimer P.D. Anesth Analg. 2010 Jul;111(1):143-8.
Severe Methemoglobinemia Detected by Pulse Oximetry. Annabi E.H., Barker S,J. Anesth Analg. 2009;108:898–9.
The Prevalence of Methemoglobin in HIV Infected Patients on Chronic Dapsone Therapy for Prophylaxis of Pneumocystis jirovecii Infection. O'Neal H.R. Crit Care Med. 2008 Vol. 36(12) (Suppl):682.
The Measurement of Dyshemoglobins and Total Hemoglobin by Pulse Oximetry. Barker S.J., Badal J.J. Curr Opin Anaesthesiol. 2008 Dec;21(6):805-10.
Do Pulse CO-Oximeter Measures of SpMet and SpO2 Correlate with Blood Gas CO-Oximetry in Neonates? Goldstein M.R., Saesim D., Macknet M., Allard M., Peverini R. Anesthesiology. 2008; 109 A1218.
Benzocaine Induced Methhemoglobin after T.E.E Macknet M.R., Kimball-Jones P.L. Applegate R.L., Martin R.D., Allard M.W. Respir Care. 2007;52(11).
Rad-57 Rainbow CO-Oximeter in Detecting Methemoglobin during Upper GI Endoscopy - A Case Report Padakandla U.B. Anesthesiology. 2007; 107: A1543.
Measurement of Carboxyhemoglobin and Methemoglobin by Pulse Oximetry: A Human Volunteer Study. Barker S.J., Curry J., Redford D., Morgan S. Anesthesiology. 2006 Nov;105(5):892-7.
Noninvasive Monitoring for Methemoglobinemia after Topical Application of Benzocaine during Upper Endoscopy and Trans-esophageal Echocardiography Schembre D., Ayub K., Gibbons E., Simmons S., Hampson N. Gastroenterol. 126(4) April 2004 Supplement 2. W1284.

* Abstracts of studies subsequently published in scientific journals and duplicate abstracts or publications are excluded.

indicates an abstract or presentation.

indicates peer-reviewed journal article.